Thursday, October 31, 2019

Episode 55 Intro | TAPP Radio Preview


A brief preview of the upcoming full episode, featuring upcoming topics—mostly about whether proper spelling and letter case is important in teaching A&P—plus word dissections, a book club recommendation of Endurance: My Year in Space, A Lifetime of Discovery, and more!

00:19 | Topics
01:45 | Sponsored by HAPI Online Graduate Program
02:29 | Word Dissection
16:07 | Sponsored by HAPS
16:34 | Book Club
19:52 | Sponsored by AAA
20:14 | Staying Connected

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Episode 55

 

Upcoming Topics

1.5 minutes

  • Communication, clarity, & nedical Errors
  • Is spelling important?
  • Alternate spellings
  • A case for proper case
  • Professionalism in the syllabus, focusing mainly on professional communication being part of our course

 

Word Dissections

13.5 minutes

  • perineum, perinea, perineal
  • peritoneum, peritonea, peritoneal
  • femur, femoral
  • fibula, fibulas, fibulae
  • letter case (type case)

Letter case

 

Book Club

3.5 minutes

  • Endurance: My Year in Space, A Lifetime of Discovery Kindle Edition
  • Special opportunity
    • Contribute YOUR book recommendation for A&P teachers!
    • First five submitted and used will be in a drawing for a Kindle Fire HD 10 tablet
    • Any contribution used will receive a $25 gift certificate
    • The best contribution is one that you have recorded in your own voice (or in a voicemail at 1-833-LION-DEN)
  • Check out The A&P Professor Book Club

Endurance book cover

If the hyperlinks here are not active, go to TAPPradio.org to find the episode page.

 

Sponsors
 
Transcript and captions for this episode
are supported by the 
 
 
also provides marketing support for this podcast. 
 
 
Distribution of this episode is supported by 
NYCC's online graduate program in 
 
Clicking on sponsor links 
helps let them know you appreciate
their support of this podcast!
 
Referrals also help defray podcasting expenses. 
 
Follow The A&P Professor on  Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram!
 
The A&P Professor® and Lion Den® are registered trademarks of Lion Den Inc. (Kevin Patton)

 

 

Click here to listen to this episode—or access the detailed notes and transcript.

Monday, October 21, 2019

Revisiting A&P Learning Outcomes | Episode 54


Host Kevin Patton previews the newly revised HAPS Learning Outcomes for A&P, discussing the goals of the revision and samples a few of the changes. Why is noon a good time to get your flu shot? Are there neurons that actively erase memories? Vaping: why A&P teachers need to keep up with the news.

00:42 | Timing of Vaccinations
02:36 | Sponsored by HAPS
03:04 | Neurons That Erase Memory
08:22 | Sponsored by AAA
08:47 | Vaping
13:45 | Sponsored by HAPI Online Graduate Program
14:28 | Revisiting the HAPS Learning Outcomes for A&P
41:43 | Staying Connected

If you cannot see or activate the audio player click here.

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It is what we think we know already that often prevents us from learning. (Claude Bernard)

 

Timing of Vaccinations

2 minutes

With a new flu season upon us, vaccination is a timely topic. Recent research suggests that the time of day at which we receive our vaccination may influence it's effectiveness. At midday, CD8 T cells may respond more strongly than at other times of day.

  • Immune cells called T cells multiply after vaccination in the middle of the day. (journal news article) my-ap.us/2LOv2tN
  • The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways (journal research article) my-ap.us/2OkPGTY
  • Australia Just Had a Bad Flu Season. That May Be a Warning for the U.S. (news article) my-ap.us/2OmPC6n
  • Frequently Asked Influenza (Flu) Questions: 2019-2020 Season (CDC info) my-ap.us/33oTN5H
  • Weekly U.S. Influenza Surveillance Report — Flu View (CDC updates) my-ap.us/326MEa2

 vaccination

 

Sponsored by HAPS

0.5 minute

The Human Anatomy & Physiology Society (HAPS) is a sponsor of this podcast.  You can help appreciate their support by clicking the link below and checking out the many resources and benefits found there. There are a bunch of 1-day regional workshops scattered all over the continent. There's probably one near you coming up this year (or next)!

 HAPS logo

 

Neurons That Erase Memory

5.5 minutes

New evidence suggests that there is a population of neurons that actively erase old, unimportant memories during REM sleep. Hopefully, your memories of past episodes of this podcast will be preserved (as well as the date of my birthday).

  • Scientists Identify Neurons That Help the Brain Forget: In mice, cells in the hypothalamus clear out old memories while the animals sleep. (news article) my-ap.us/2OkxEkV
  • REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories (journal report) my-ap.us/2MfVyvl

 neurons

 

Sponsored by AAA

0.5 minutes

 AAA logo

 

Vaping

5 minutes

Vaping is a timely topic, considering the emergence of vaping-induced lung injury and other vaping-related conditions. Discussing the news about vaping, which is frequently updated, is appropriate in the A&P course. Following the story over the course of a year may helps students better understand human science.

  • Vaping Illnesses Top 1,000, C.D.C. Says (news article) my-ap.us/2MgPUZL
  • Lung Damage From Vaping Resembles Chemical Burns, Report Says (news article) my-ap.us/2IoMZxa
  • Vaping-Induced Lung Injury (journal editorial) my-ap.us/2MhP2UH
  • The Health Effects of Electronic Cigarettes (journal review article) my-ap.us/2OnST5b
  • How Vaping Nicotine Can Affect A Teenage Brain (print/audio news story) my-ap.us/32b5OvG
  • CDC Vaping Information (search results showing current information) my-ap.us/2Mch70I
  • A Young Man Nearly Lost His Life to Vaping (newspaper article) my-ap.us/2qfkdZn
  • Vaping-related illness has a new name: EVALI (news article) my-ap.us/2MOaUau
  • Update: Interim Guidance for Health Care Providers Evaluating and Caring for Patients with Suspected E-cigarette, or Vaping, Product Use Associated Lung Injury — United States, October 2019 (CDC update) my-ap.us/33Cag6U

 vaping

 

Sponsored by HAPI Online Graduate Program

1 minute

The Master of Science in Human Anatomy & Physiology Instruction—the MS-HAPI—is a graduate program for A&P teachers. A combination of science courses (enough to qualify you to teach at the college level) and courses in contemporary instructional practice, this program helps you power up  your teaching. Kevin Patton is a faculty member in this program. Check it out!

 NYCC Human Anatomy and Physiology Instruction

 

Revisting the A&P Learning Outcomes from HAPS

27 minutes

HAPS recently released its revised Learning Outcomes for A&P. It's a significant revision, with many improvements. Kevin discusses some of the changes and gives advice on how to navigate and use them in your course.

  • HAPS Learning Outcomes (download page for outcomes and white paper; requires login) my-ap.us/2noTclo
    • Module titles:
      • A: Body Plan & OrganizationB: HomeostasisC: Chemistry & Cell Biology

        D: Histology

        E: Integumentary System

        F: Skeletal System & Articulations

        G: Muscular System

        H: Nervous System

        I: General and Special Senses

        J: Endocrine System

        K: Cardiovascular System

        L: Lymphatic system and immunity

        M: Respiratory System

        N: Digestive system

        O: Nutrients & Metabolism

        P: Urinary System

        Q: Fluid/Electrolytes & Acid-Base Balance

        R: Reproductive System

        S: Introduction to Heredity

        T: Embryology

heart

 

If the hyperlinks here are not active, go to TAPPradio.org to find the episode page.

 

Sponsors
 
Transcript and captions for this episode
are supported by the 
 
 
also provides marketing support for this podcast. 
 
 
Distribution of this episode is supported by 
NYCC's online graduate program in 
 
Clicking on sponsor links 
helps let them know you appreciate
their support of this podcast!
 
Referrals also help defray podcasting expenses. 
 
Follow The A&P Professor on  Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram!
 
The A&P Professor® and Lion Den® are registered trademarks of Lion Den Inc. (Kevin Patton)
 

Click here to listen to this episode—or access the detailed notes and transcript.

Wednesday, October 16, 2019

Episode 54 Intro | TAPP Radio Preview


A brief preview of the upcoming full episode 54, featuring upcoming topics that include a brief discussion of the newly revised A&P Learning Outcomes from HAPS, updates regarding timing of vaccinations, a newly discovered type of neuron that erases old memories, and vaping.

Episode 54

There's more... some word dissections and Kevin's recommendation for The A&P Professor Book Club.

 

If you cannot see or activate the audio player click here.

Questions & Feedback: 1-833-LION-DEN (1-833-546-6336)

Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram!

 

Topics

2 minutes

  • Newly revised A&P Learning Outcomes from HAPS
  • Timing of vaccinations matters
  • Newly discovered neurons actively erase old memories
  • Vaping-related lung problems

Word Dissections

9.5 minutes

  • isovolumic & isovolumetric
  • hemopoiesis & hematopoiesis
  • vaccination
  • CD8 T cell

 

isovolumic vs. isovolumetric

Book Club

5.5 minutes

  • Human Errors: A Panorama of Our Glitches, from Pointless Bones to Broken Genes
  • Special opportunity
    • Contribute YOUR book recommendation for A&P teachers!
    • First five submitted and used will be in a drawing for a Kindle Fire HD 10 tablet
    • Any contribution used will receive a $25 gift certificate
    • The best contribution is one that you have recorded in your own voice (or in a voicemail at 1-833-LION-DEN)
  • Check out The A&P Professor Book Club

 

Human Errors book

If the hyperlinks here are not active, go to TAPPradio.org to find the episode page.

 

Sponsors
 
Transcript and captions for this episode
are supported by the 
 
 
also provides marketing support for this podcast. 
 
 
Distribution of this episode is supported by 
NYCC's online graduate program in 
 
Clicking on sponsor links 
helps let them know you appreciate
their support of this podcast!
 
Referrals also help defray podcasting expenses. 
 
Follow The A&P Professor on  Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram!
 
The A&P Professor® and Lion Den® are registered trademarks of Lion Den Inc. (Kevin Patton)
 

Click here to listen to this episode—or access the detailed notes and transcript.

Monday, October 7, 2019

Cells & Oxygen Availability | Nobel Special | Episode 54 Bonus


Host Kevin Patton summarizes the 2019 Nobel Prize in Physiology or Medicine to three scientists "for their discoveries of how cells sense and adapt to oxygen availability." A special bonus episode.

00:41 | Introduction to Bonus Episode
02:00 | Sponsored by HAPS
02:24 | Summary of Discovery
04:13 | Oxygen at Center Stage
05:24 | HIF Enters the Scene
08:08 | Sponsored by AAA
08:26 | VHL - An Unexpected Partner
11:37 | Oxygen sHIFts the Balance
13:20 | Oxygen Shapes Physiology & Pathology
15:15 | Sponsored by HAPI Online Graduate Program
15:48 | Our Course
23:46 | Staying Connected

If you cannot see or activate the audio player click here.

Questions & Feedback: 1-833-LION-DEN (1-833-546-6336)

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Singing is like a celebration of oxygen. (Björk)

 

1 | Introduction to the Bonus Episode

1 minute

Kevin introduces the bonus episode, explaining that he's sharing the press release for the 2019 Nobel Prize in Physiology or Medicine. It's chunked for clarity.

Press release: The Nobel Prize in Physiology or Medicine 2019. NobelPrize.org. Nobel Media AB 2019. Mon. 7 Oct 2019. <https://www.nobelprize.org/prizes/medicine/2019/press-release/>

 

2 | Sponsored by HAPS

2 minutes

The Human Anatomy & Physiology Society (HAPS) is a sponsor of this podcast.  You can help appreciate their support by clicking the link below and checking out the many resources and benefits found there. There are a bunch of 1-day regional workshops scattered all over the continent. There's probably one near you coming up this year (or next)!

Anatomy & Physiology Society 

theAPprofessor.org/haps

 HAPS logo

 

3 | Summary of the Discovery

2 minutes

  • 2019-10-07: The Nobel Assembly at Karolinska Institutet has today decided to award the 2019 Nobel Prize in Physiology or Medicine jointly to William G. Kaelin Jr., Sir Peter J. Ratcliffe, and Gregg L. Semenza for their discoveries of how cells sense and adapt to oxygen availability.
  • They identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.

 

4 | Oxygen at Center Stage

1 minute

During evolution, mechanisms developed to ensure a sufficient supply of oxygen to tissues and cells.

 

5 | HIF Enters the Scene

3 minutes

  • Gregg Semenza studied the EPO (erythropoietin) gene and how it is regulated by varying oxygen levels.
  • In cultured liver cells he discovered a protein complex that binds to the identified DNA segment in an oxygen-dependent manner. He called this complex the hypoxia-inducible factor (HIF).
  • HIF was found to consist of two different DNA-binding proteins, so called transcription factors, now named HIF-1α and ARNT.

 

6 | Sponsored by AAA

0.5 minutes

 AAA logo

 

7 | VHL - An Unexpected Partner

3 minutes

  • When oxygen levels are high, cells contain very little HIF-1α. However, when oxygen levels are low, the amount of HIF-1α increases so that it can bind to and thus regulate the EPO gene as well as other genes with HIF-binding DNA segments.
  • At about the same time as Semenza and Ratcliffe were exploring the regulation of the EPO gene, cancer researcher William Kaelin, Jr. was researching an inherited syndrome, von Hippel-Lindau’s disease (VHL disease).
    • VHL is part of a complex that labels proteins with ubiquitin, marking them for degradation in the proteasome.
    • Ratcliffe and his research group then made a key discovery: demonstrating that VHL can physically interact with HIF-1α and is required for its degradation at normal oxygen levels. This conclusively linked VHL to HIF-1α.

Hypoxia diagram When oxygen levels are low (hypoxia), HIF-1α is protected from degradation and accumulates in the nucleus, where it associates with ARNT and binds to specific DNA sequences (HRE) in hypoxia-regulated genes (1). At normal oxygen levels, HIF-1α is rapidly degraded by the proteasome (2). Oxygen regulates the degradation process by the addition of hydroxyl groups (OH) to HIF-1α (3). The VHL protein can then recognize and form a complex with HIF-1α leading to its degradation in an oxygen-dependent manner (4). https://my-ap.us/35fm0O6

 

8 | Oxygen sHIFts the Balance

1.5 minutes

  • It was also shown that the gene activating function of HIF-1α was regulated by oxygen-dependent hydroxylation.
  • The Nobel Laureates had now elucidated the oxygen sensing mechanism and had shown how it works.

 

9 | Oxygen Shapes Physiology & Pathology

2 minutes

  • Thanks to the groundbreaking work of these Nobel Laureates, we know much more about how different oxygen levels regulate fundamental physiological processes.
    • For example, muscles, blood vessel formation, immunity, RBC production, placenta development, etc.
  • Oxygen sensing is central to a large number of diseases.
    • For example, patients with chronic renal failure often suffer from severe anemia due to decreased EPO expression. See figure (if you cant's see it, go to https://my-ap.us/2LW2cIb)

Importance of this discovery The awarded mechanism for oxygen sensing has fundamental importance in physiology, for example for our metabolism, immune response and ability to adapt to exercise. Many pathological processes are also affected. Intensive efforts are ongoing to develop new drugs that can either inhibit or activate the oxygen-regulated machinery for treatment of anemia, cancer and other diseases. https://my-ap.us/2LW2cIb

 

10 | Sponsored by HAPI Online Graduate Program

1 minute

The Master of Science in Human Anatomy & Physiology Instruction—the MS-HAPI—is a graduate program for A&P teachers. A combination of science courses (enough to qualify you to teach at the college level) and courses in contemporary instructional practice, this program helps you power up  your teaching. Kevin Patton is a faculty member in this program. Check it out!

nycc.edu/hapi

 NYCC Human Anatomy and Physiology Instruction

 

11 | Our Course

8 minutes

  • This set of discoveries touches on many of the core concepts of our course (the big ideas of our story of the human body).
  • Nobel Prizes are a cultural touchstone that students can related to, and thus increase interest and motivation.
  • Nobel Prizes can be a starting point for discussion the role of science in the context of society and culture.
  • Additional resources:
    • Main page for this prize: my-ap.us/31Wuc3Z
    • Publications
      • Semenza, G.L, Nejfelt, M.K., Chi, S.M. & Antonarakis, S.E. (1991). Hypoxia-inducible nuclear factors bind to an enhancer element located 3’ to the human erythropoietin gene. Proc Natl Acad Sci USA, 88, 5680-5684 my-ap.us/2ontmP8

      • Wang, G.L., Jiang, B.-H., Rue, E.A. & Semenza, G.L. (1995). Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA, 92, 5510-5514 my-ap.us/2IxLUD5

      • Maxwell, P.H., Wiesener, M.S., Chang, G.-W., Clifford, S.C., Vaux, E.C., Cockman, M.E., Wykoff, C.C., Pugh, C.W., Maher, E.R. & Ratcliffe, P.J. (1999). The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature, 399, 271-275 my-ap.us/2op4XbP

      • Mircea, I., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J.M., Lane, W.S. & Kaelin Jr., W.G. (2001) HIFa targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science, 292, 464-468 my-ap.us/2IxIf8t

      • Jakkola, P., Mole, D.R., Tian, Y.-M., Wilson, M.I., Gielbert, J., Gaskell, S.J., von Kriegsheim, A., Heberstreit, H.F., Mukherji, M., Schofield, C.J., Maxwell, P.H., Pugh, C.W. & Ratcliffe, P.J. (2001). Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science, 292, 468-472 my-ap.us/35i4wR9

 

If the hyperlinks here are not active, go to TAPPradio.org to find the episode page.

 

Sponsors
 
Transcript and captions for this episode
are supported by the 
 
 
also provides marketing support for this podcast. 
 
 
Distribution of this episode is supported by 
NYCC's online graduate program in 
 
Clicking on sponsor links 
helps let them know you appreciate
their support of this podcast!
 
Referrals also help defray podcasting expenses. 
 
Follow The A&P Professor on  Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram!
 
The A&P Professor® and Lion Den® are registered trademarks of Lion Den Inc. (Kevin Patton)
 

Click here to listen to this episode—or access the detailed notes and transcript.