Monday, August 18, 2014

Human Microbial System

A recent article in The Scientist once again reminds us of the ongoing explosion in the scientific understanding of the human microbial system.  In a few short years, this area of exploration has moved to the forefront of medical and basic science research in human biology.

I think it's becoming clear that the most useful way to think of human body function is to recognize that an "organism" is really a sort of "habitat."  And like any habitat, it functions best when all the inhabitants are within a limited range of balanced relationships.

Who are the inhabitants?  Besides our own cells?  Well, one could think of mitochondria and cilia and other organelles as symbiotic internal inhabitants of our cells.  They're not that literally, of course, but I think its a useful metaphor for understanding the human body.  Then there are the many microbes and animals that cover our internal and external surfaces, burrow into some of our pores and glands, and inhabit our body fluids.

I call the balanced functional relationship among the various microbomes of the body and our own tissues the human microbial system.  And I am certain that it won't be long before we will be discussing this system alongside the major organ systems of the body.  That is if we truly want to understand how the body really works.

The article in The Scientist I mention is a great summary of some of the major roles that the human microbial system plays in the human body—and a good survey of some of the areas of the body where the human-microbial functional relationships play out.  See the link to the article below.

What can we use from this in teaching undergraduate A&P?

  • Why not introduce the concept of the human microbial system at the beginning of our A&P course, when we set the stage by explain how scientists understand the body and its functions as an integrated system of different parts?
  • We can mention the different microbiomes of the body when we explore each organ system where they play an important role—which is pretty much all of them!
  • Consider discussing what happens to normal human function when microbiomes get out of balance.  For example, in the gut a microbial imbalance can lead to ulcers, diarrhea, and other dysfunctions.  On the skin a pathogenic microbe may become dominant and cause a rash.
  • Promote a discussion of what kinds of wellness strategies might be employed to prevent microbial imbalances.
  • Our students can leave our A&P course with an up-to-date understanding of human biology that will help them understand new clinical concepts and treatment strategies.

Want to Know More?

The Body’s Ecosystem

  • By The Scientist Staff.  The Scientist. August 1, 2014
  • Plain-English article (cited above) on how research on the human microbiome is booming, and scientists have moved from simply taking stock of gut flora to understanding the influence of microbes throughout the body.

Articles from The A&P Professor

Moving pictures of the human microbiome

  • J Gregory Caporaso et al. Genome Biology 2011, 12:R50  doi:10.1186/gb-2011-12-5-r50
  • Open-access journal article that includes FREE videos that show how dynamic the human microbial system is

Human Microbiome Project

The Microbiome and Disease

  • List of diseases associated with microbiome imbalances from Genetic Science Learning Center


  • Radio stories from National Public Radio on human microbiomes and their role in health and disease.  The growing number of these stories tells us something as A&P teachers: maybe we better be covering this!

No comments:

Post a Comment