Secretin is already known to be secreted from the intestinal lining, having a variety of effects in regulating stomach and pancreatic function during the digestive process. New findings indicate, however, that secretin is also secreted by the posterior pituitary.
Neurohypophysial release of secretin is triggered by plasma hyperosmolality—as in dehydration of the body. Secretin then promotes the expression and release of ADH, which in turn promotes water conservation by the kidney. Secretin also appears to have direct water-conserving effects in the kidney as well.
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Secretin as a neurohypophysial factor regulating body water homeostasis
Jessica Y. S. Chu, et al.
Proceedings of the National Academy of Science September 15, 2009 vol. 106 no. 37 15961-15966
[Abstract of the recent paper.]
Highlights From The Literature
Physiology 2009 24:322-324
[Summary of the significance of this discovery.]
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