Metabolism Case Study

This just in from the National Center for Case Study Teaching in Science . . .

Our latest case study is “Why Is Patrick Paralyzed?” by Maureen Knabb, Department of Biology, West Chester University.

This clicker case introduces students to a rare genetic disease in which an enzyme is deficient in a critical metabolic pathway—the first step in aerobic respiration. This case challenges students to make connections between energy production, enzymes, and metabolic diseases.

Students are exposed to a real life story that serves as a basis for discussing the uses of energy-rich molecules and the importance of complex metabolic pathways catalyzed by protein enzymes.

Overall, students should appreciate the importance of each step in a metabolic pathway and the side effects as well as treatments that can emerge from discovering the underlying enzyme deficiency.

Case: http://www.sciencecases.org/patrick_paralyzed/prelude.asp

Teaching Notes: http://www.sciencecases.org/patrick_paralyzed/notes.asp

Case Collection: http://ublib.buffalo.edu/libraries/projects/cases/ubcase.htm

This module also includes a nice PowerPoint slide presentation.

If you use this case in your course, why not let us know how it works for you?